Overview

  • Product nameAnti-PRDM6 antibody
    See all PRDM6 primary antibodies
  • Description
    Rabbit polyclonal to PRDM6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 43-72 of Human PRDM6 (NP_001129711.1).

  • Positive control
    • Jurkat cell line lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab123317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 64 kDa.

Target

  • FunctionPutative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
  • Sequence similaritiesContains 4 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gm92 antibody
    • PFM3 antibody
    • PR domain containing 6 antibody
    • PR domain containing protein 6 antibody
    • PR domain zinc finger protein 6 antibody
    • PR domain-containing protein 6 antibody
    • Prdm6 antibody
    • PRDM6_HUMAN antibody
    • PRISM antibody
    • Putative histone-lysine N-methyltransferase PRDM6 antibody
    • RGD1559594 antibody
    see all

Anti-PRDM6 antibody images

  • Anti-PRDM6 antibody (ab123317) at 1/100 dilution + Jurkat cell line lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 64 kDa

References for Anti-PRDM6 antibody (ab123317)

ab123317 has not yet been referenced specifically in any publications.

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