Overview

  • Product nameAnti-Presenilin 1 + 2 antibody
  • Description
    Rabbit polyclonal to Presenilin 1 + 2
  • Tested applicationsELISA, WB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) conjugated to KLH, in the region of amino acids 126-143 of Human Presenilin 1 and Presenilin 2.

  • Positive control
    • Hela cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab60120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA
WB
  • Application notesELISA: 1/1000.
    WB: 1/100 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: Presenilin 1 53 kDa; Presenilin 2 50 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
    • Cellular localizationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface.
    • Database links
    • Alternative names
      • AD 3 antibody
      • AD4 antibody
      • AD5 antibody
      • Alzheimer disease 3 antibody
      • Alzheimer disease 4 antibody
      • FAD antibody
      • Presenilin 1 antibody
      • Presenilin 2 antibody
      • Presenilin1 antibody
      • PS1 antibody
      • PS2 antibody
      • PSEN1 antibody
      • PSEN2 antibody
      • STM2 antibody
      see all

    Anti-Presenilin 1 + 2 antibody images

    References for Anti-Presenilin 1 + 2 antibody (ab60120)

    ab60120 has not yet been referenced specifically in any publications.

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