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Storage instructions Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Storage buffer Preservative: 0.09% Sodium azide Constituent: 99% PBS
Concentration information loading...
Purity Immunogen affinity purified
Purification notes ab112950 is purified through a protein A column, followed by peptide affinity purification.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 186 kDa.
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Tissue specificity Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Sequence similarities Contains 1 DEP domain. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PH domains.
Cellular localization Cytoplasm > cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Information by UniProt
5)-dependent Rac exchanger 1 antibody
Anti-PREX1 antibody images
References for Anti-PREX1 antibody (ab112950)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"