FunctionFunctions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Tissue specificityMainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 protein antibody
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein antibody
PtdIns(3,4,5) dependent Rac exchanger 1 antibody
SET domain containing 6 antibody
References for Anti-PREX1 antibody (ab124231)
This product has been referenced in:
Cardama GA et al. Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines. Anticancer Agents Med Chem14:840-51 (2014).
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