Overview

  • Product name
  • Description
    Rabbit polyclonal to PREX1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human PREX1 aa 635-869. The exact sequence is proprietary.
    Database link: Q8TCU6

  • Positive control
    • MCF7 whole cell lysate; PREX1 transfected 293T whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab183638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 186 kDa.

Target

  • Function
    Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
  • Tissue specificity
    Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
  • Sequence similarities
    Contains 1 DEP domain.
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 PH domains.
  • Cellular localization
    Cytoplasm > cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5)-dependent Rac exchanger 1 antibody
    • KIAA1415 antibody
    • OTTHUMP00000031228 antibody
    • P REX1 antibody
    • P Rex1 protein like antibody
    • P-Rex1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchange factor 1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 protein antibody
    • Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein antibody
    • Prex1 antibody
    • PREX1_HUMAN antibody
    • PtdIns(3 antibody
    • PtdIns(3,4,5) dependent Rac exchanger 1 antibody
    • SET domain containing 6 antibody
    • Setd6 antibody
    see all

Images

  • Anti-PREX1 antibody (ab183638) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

    Predicted band size : 186 kDa

    5 % SDS-PAGE

  • All lanes : Anti-PREX1 antibody (ab183638) at 1/5000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Whole cell lysate of Human PREX1 transfected 293T cells

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 186 kDa

    5 % SDS-PAGE

References

ab183638 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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