All tags RabMAb Antibodies for Parkinson's disease targets

Antibodies for Parkinson's disease targets

High-quality rabbit monoclonal antibodies for key Parkinson's disease targets.

​​To provide the tools you need for Parkinson’s disease research, we partnered with the Michael J. Fox Foundation to develop rabbit monoclonal antibodies for leucine-rich repeat kinase 2 (LRRK2), alpha-synuclein, and DJ-1.


LRRK2 

LRRK2 gene mutation is the most common cause of inherited Parkinson's disease. While it is the focus of intensive research in the Parkinson's field, a lack of high-quality LRRK2 antibodies has been a major roadblock to the successful development of LRRK2-based therapies.

After primary characterization organized by MJFF and feedback from the Parkinson’s disease research community, three rabbit monoclonal clones exhibiting the best performance were selected for distribution via Abcam.

"LRRK2 antibodies are critical to help move Parkinson's research forward. The three unique clones chosen for initial release were identified based on several months of testing by our large network of PD researchers... we are excited that they [Abcam] will continue to help MJFF remove barriers to developing Parkinson's therapies."

- Dr. Mark Frasier, Vice President of Research Programs at MJFF

LRRK2 antibodies

Antibody nameClone IDApplicationsSpeciesAbID
LRRK2MJFF2
(c41-2)
ICC/IF, IHC-FrFl, IHC-P, IP, WB Hu, Ms, Rtab133474
LRRK2MJFF3
(c69-6)
ICC/IF, IHC-P, IP, WBHu, Ms, Rtab133475
LRRK2MJFF4 
(c81-8)
ICC/IF, IHC-P, IP, WBHu, Ms, Rtab133476
LRRK2MJFF5 (68-7)WBHu, Msab181386
LRRK2UDD3 30(12)ICC/IF, IHC-P, WBHu, Msab133518
LRRK2 
(phospho S910)
UDD1 15(3)WBHuab133449
LRRK2 
(phospho S935)
UDD2 10(12)ICC/IF, WBHu, Msab133450
LRRK2 (phospho S955)MJF-R11 (75-1)WBHu, Msab169521
LRRK2 (phospho S973)MJF-R12 (37-1)WBHuab181364
LRRK2 (phospho T1410)MJFR4-25-5WBHu, Ms, Rtab140107
LRRK2 
(phospho T1491)
MJFR5-88-3WBHuab140106

LRRK2 (phospho T1503)

MJF-R6
(227-1a)
WBHuab154423
LRRK2 (phospho S1292)MJFR-19-7-8WBHuab203181
LRRK2 (phospho T2483)MJF-R8
(21-2e)
WBHuab156577

​​​See a complete list of LRRK2 antibodies and their characterization data.


Alpha-synuclein 

Alpha-synuclein was the first gene to be linked to Parkinson’s disease and remains the most promising link to PD pathogenesis. Alpha-synuclein is a major component of Lewy bodies, a cardinal feature of PD pathology.

Synuclein antibodies

Antibody nameClone IDApplicationsSpeciesAbID
Alpha-synucleinMJFR1ELISA, Flow Cyt, ICC/IF, IHC-P, IP, WBHu, Drosophila melanogasterab138501
Alpha-synuclein (phospho S129)MJF-R13
(8-8)
WBHuab168381
Alpha synuclein filament - conformation specificMJFR-14-6-4-2ICC/IF, IHC-P, dot blotHu, Ms, Rtab209538


DJ-1

DJ-1 (PARK7) is thought to act as a sensor of oxidative stress in cells. It has increasingly been investigated for modifications that occur as a result of disease pathogenesis, including protein oxidation. 

DJ-1 antibody

Antibody nameClone IDApplicationSpeciesAbID
DJ1 (PARK7)MJF-R16
(66-5)
WBHuab169520


About Michael J. Fox Foundation

The Michael J. Fox Foundation is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today.

Learn more about the Michael J.Fox Foundation.

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