1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
Application notesIs unsuitable for IHC-P or IP.
Tissue specificityHigh levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.
Involvement in diseaseNote=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.
All lanes : Anti-PRKX antibody [EPR4840] (ab109389) at 1/1000 dilution
Lane 1 : A549 cell lysates Lane 2 : Jurkat cell lysates Lane 3 : 293T cell lysates Lane 4 : Human fetal kidney lysates Lane 5 : Human fetal brain lysates
Lysates/proteins at 10 µg per lane.
Predicted band size : 41 kDa
References for Anti-PRKX antibody [EPR4840] (ab109389)
This product has been referenced in:
Ouyang C et al. Transforming Growth Factor (TGF)-ß-activated Kinase 1 (TAK1) Activation Requires Phosphorylation of Serine 412 by Protein Kinase A Catalytic Subunit a (PKACa) and X-linked Protein Kinase (PRKX). J Biol Chem289:24226-37 (2014).
Read more (PubMed: 25028512) »