Overview

  • Product name
  • Description
    Goat polyclonal to PRMT2
  • Host species
    Goat
  • Specificity
    ab156801 is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Pig
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:

    DQPRTTKYHSVILQ

    with a Cysteine residue linker, corresponding to internal sequence amino acids 118-131 of Human PRMT2.

  • Positive control
    • HeLa cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab156801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 37 kDa.

Approx 37kDa band observed in lysates of cell line HeLa and in rodent Brain lysates (calculated MW of 37.2kDa according to NP_001229793.1). Approx 35kDa band observed in Pig Brain lysates (calculated MW of 38.7kDa according to XP_005658963.1).

Target

  • Function
    Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
  • Tissue specificity
    Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
  • Sequence similarities
    Belongs to the protein arginine N-methyltransferase family.
    Contains 1 SH3 domain.
  • Cellular localization
    Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANM2_HUMAN antibody
    • EC 2.1.1. antibody
    • histone arginine N methyltransferase PRMT2 antibody
    • Histone-arginine N-methyltransferase PRMT2 antibody
    • HMT 1 antibody
    • HMT1 (hnRNP methyltransferase S. cerevisiae) like 1 antibody
    • HMT1 antibody
    • HMT1 hnRNP methyltransferase like 1 antibody
    • hnRNP methyltransferase (S. cerevisiae) like 1 antibody
    • hnRNP methyltransferase like 1 antibody
    • Hrmt1l1 antibody
    • MGC111373 antibody
    • PRMT 2 antibody
    • PRMT2 alpha antibody
    • prmt2 antibody
    • PRMT2 beta antibody
    • PRMT2 gamma antibody
    • PRMT2 protein antibody
    • PRMT2L2 antibody
    • Protein arginine methyltransferase 2 antibody
    • Protein arginine N methyltransferase 2 antibody
    • Protein arginine N-methyltransferase 2 antibody
    • Zf2 antibody
    see all

Images

  • Anti-PRMT2 antibody (ab156801) at 2 µg/ml + Pig brain lysate at 35 µg

    Predicted band size: 37 kDa

  • All lanes : Anti-PRMT2 antibody (ab156801) at 2 µg/ml

    Lane 1 : Mouse brain lysate
    Lane 2 : Rat brain lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size: 37 kDa

  • Anti-PRMT2 antibody (ab156801) at 2 µg/ml + HeLa cell lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 37 kDa

References

ab156801 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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