• Product nameAnti-PRMT7 antibody
    See all PRMT7 primary antibodies
  • Description
    Rabbit polyclonal to PRMT7
  • Specificityab22110 reacts with protein arginine methyltransferase 7 (PRMT7).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 346-360 of Human PRMT7. This amino acid sequence can be found in five different human PRMT7 isoforms: CRA_a (692 amino acids), CRA_b (613 amino acids), CRA_c (465 amino acids), CRA_d (655 amino acids) and CRA_e (567 amino acids)

  • Positive control
    • HeLa or NIH 3T3 cell lysate


Associated products


Our Abpromise guarantee covers the use of ab22110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 µg/ml. Detects a band of approximately 68 kDa.


  • FunctionArginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
  • Involvement in diseaseDefects in PRMT7 are associated with mild intellectual disabilityy, obesity and symmetrical shortening of the digits and posterior metacarpals and metatarsals. The phenotype is a phenocopy of pseudohypoparathyroidism (PHP).
  • Sequence similaritiesBelongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
    Contains 2 SAM-dependent MTase PRMT-type domains.
  • Cellular localizationCytoplasm, cytosol. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • [Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody
    • ANM7_HUMAN antibody
    • FLJ10640 antibody
    • Histone-arginine N-methyltransferase PRMT7 antibody
    • KIAA1933 antibody
    • Myelin basic protein arginine N methyltransferase antibody
    • OTTHUMP00000174863 antibody
    • PRMT7 antibody
    • Protein arginine methyltransferase 7 antibody
    • Protein arginine N-methyltransferase 7 antibody
    see all

Anti-PRMT7 antibody images

  • All lanes : Anti-PRMT7 antibody (ab22110) at 2 µg/ml

    Lane 1 : HeLa Cell Lysate
    Lane 2 : NIH 3T3 Cell Lysate

References for Anti-PRMT7 antibody (ab22110)

This product has been referenced in:
  • Verbiest V  et al. Protein arginine (N)-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins. FEBS Lett 582:1483-9 (2008). WB ; Human . Read more (PubMed: 18381071) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Human fibroblast cell line)
Loading amount 25 µg
Specification Human fibroblast cell line
Treatment Overexpression of HIS-tagged PRMT-7 expressing plasmid
Gel Running Conditions Reduced Denaturing (10 % SDS-PAGE gel ran in BioRad Tetracell apparatus)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

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Submitted Mar 07 2011