Overview

  • Product name
  • Description
    Mouse polyclonal to PRMT8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Full length protein, corresponding to amino acids 1-394 of Human PRMT8 (NP_062828.3).

  • Positive control
    • PRMT8 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.

Target

  • Function
    Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.
  • Tissue specificity
    Brain-specific.
  • Sequence similarities
    Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily.
  • Domain
    The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.
    The N-terminal region (1-60) inhibits the enzymatic activity.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANM8_HUMAN antibody
    • Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 4 antibody
    • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 antibody
    • HMT1 hnRNP methyltransferase like 3 antibody
    • HMT1 hnRNP methyltransferase like 4 antibody
    • HRMT1 L3 antibody
    • HRMT1 L4 antibody
    • HRMT1L 3 antibody
    • HRMT1L 4 antibody
    • HRMT1L3 antibody
    • HRMT1L4 antibody
    • prmt8 antibody
    • Protein arginine N methyltransferase 4 antibody
    • Protein arginine N methyltransferase 8 antibody
    • Protein arginine N-methyltransferase 8 antibody
    see all

Images

  • All lanes : Anti-PRMT8 antibody (ab168134) at 1 µg/ml

    Lane 1 : PRMT8 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 45 kDa

References

ab168134 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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