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Anti-pro Caspase 12 antibody (ab8118)

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Overview

Product name

Anti-pro Caspase 12 antibody
See all pro Caspase 12 products (2) ...

Description

Rabbit polyclonal to pro Caspase 12

Specificity

The antibody only recognizes the prodomain, not the activated form.

Tested applications

IHC-P, ELISA, WBmore details

Cross reactivity

Reacts with

Mouse, Rat

Does not react with

Human

Immunogen

Synthetic peptide: AARRTHERDPIYKIKG, corresponding to amino acids 2-17 of Mouse Caspase 12.

AARRTHERDPIYKIKG

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Mouse spleen tissue lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.02% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Polyclonal

Isotype

IgG

Research areas

Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Caspases

  • Western blot - pro Caspase 12 antibody (ab8118)Western blot - pro Caspase 12 antibody (ab8118) image (enlarge)

  • Immunohistochemistry - pro Caspase 12 antibody (ab8118)Immunohistochemistry - pro Caspase 12 antibody (ab8118) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab8118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Caspase 12 is activated by ER stress, including disruption of ER calcium homeostasis and mediates ER stress-induced apoptosis. Caspase 12 is co-localized to the ER with several proteins that are involved in Alzheimers disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase 12 mediates cytotoxicity induced by amyloid-beta. It is ubiquitously expressed in mouse tissue.

Cellular localization

Endoplasmic reticulum

Alternative names

  • CASP12 antibody
  • CASP12P1 antibody

Database links

Anti-pro Caspase 12 antibody images:

  Western blot - pro Caspase 12 antibody (ab8118)

Western blot - pro Caspase 12 antibody (ab8118)

All lanes : Anti-pro Caspase 12 antibody (ab8118) at 1 µg/ml

Lane 1 : Human spleen tissue lysate
Lane 2 : Mouse spleen tissue lysate

  Immunohistochemistry - pro Caspase 12 antibody (ab8118)

Immunohistochemistry - pro Caspase 12 antibody (ab8118)

ab8118 at 10µg/ml staining Caspase 12 in human heart tissue by IHC

References for Anti-pro Caspase 12 antibody (ab8118)

This product has been referenced in:

  • Hauri-Hohl MM  et al. Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation. Blood 109:4080-8 (2007).Read more (PubMed: 17213290) »

See 1 publication for this product

Publishing research using ab8118? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"