Overview

  • Product nameAnti-proBDNF antibody
    See all proBDNF primary antibodies
  • Description
    Sheep polyclonal to proBDNF
  • Tested applicationsWB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Zebrafish
  • Immunogen

    A synthetic peptide from part of rat, mouse, zebrafish proBDNF conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab72430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
IHC-Fr
  • Application notesIHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
    IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
    WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 28 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
    • Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
    • Involvement in diseaseCongenital central hypoventilation syndrome
    • Sequence similaritiesBelongs to the NGF-beta family.
    • Post-translational
      modifications
      The propeptide is N-glycosylated and glycosulfated.
      Converted into mature BDNF by plasmin (PLG).
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Abrineurin antibody
      • BDNF antibody
      • BDNF_HUMAN antibody
      • Brain derived neurotrophic factor antibody
      • Brain-derived neurotrophic factor antibody
      see all

    References for Anti-proBDNF antibody (ab72430)

    ab72430 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"