Overview

  • Product nameAnti-proBDNF antibodySee all proBDNF primary antibodies ...
  • Description
    Rabbit polyclonal to proBDNF
  • SpecificityThis antibody appears to be specific for proBDNF.
  • Tested applicationsWB, IHC-P, IHC-Fr more details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    A synthetic peptide from part of rat, mouse, zebra fish proBDNF conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab72440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
IHC-Fr
  • Application notesIHC-P: Use at a concentration of 10 - 50 µg/ml. For paraffin sections antigen retrieval is recommended.
    IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
    WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 28 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceBrain derived neurotrophic factor (BDNF)is a member of the nerve growth factor family. BDNF is necessary for survival of striatal neurons in the brain and also acts as a neuroprotectant of the major neuronal types (eg. hippocampal, cortical and basal forebrain cholinergic neurons). Expression of the BDNF gene is reduced in both Alzheimer's and Huntington disease patients. Furthermore BDNF may play a role in the regulation of stress response and in the biology of mood disorders. BDNF protein is synthesized as a precursor, proBDNF, which is cleaved to the mature 14-kDa form. It is known that BDNF exists as a mixture of proBDNF and mature BDNF (PMID: 1265414). Although the biological activity of proBDNF is unclear, there is evidence suggesting that reductions in proBDNF levels affects neuronal degeneration in selective brain regions (eg. in Alzheimer's disease).
    • Cellular localizationSecreted
    • Database links
    • Alternative names
      • Abrineurin antibody
      • Brain derived neurotrophic factor antibody

    References for Anti-proBDNF antibody (ab72440)

    This product has been referenced in:
    • Scaini G  et al. Chronic administration of branched-chain amino acids impairs spatial memory and increases brain-derived neurotrophic factor in a rat model. J Inherit Metab Dis : (2012). WB . Read more (PubMed: 23109061) »
    • Cortese GP  et al. Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLC{gamma}1, and ERK in Hippocampal Synaptoneurosomes. J Neurosci 31:4274-9 (2011). WB ; Rat . Read more (PubMed: 21411668) »

    See all 2 Publications for this product

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    DISCOUNT CODE: ***

    Expiration date: August 19th, 2012

    I am very pleased to hear you would like to accept our offer and test ab72440 in IHC-FoFr. This code will give you: 1 free primary antibody before the expiration date. To redeem...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"