Overview

  • Product nameAnti-proBDNF antibody
  • Description
    Rabbit polyclonal to proBDNF
  • SpecificityThis antibody appears to be specific for proBDNF.
  • Tested applicationsIHC, WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    A synthetic peptide from part of rat, mouse, zebra fish proBDNF conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab72440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC
WB
IHC-P
IHC-Fr
  • Application notesIHC-P: Use at a concentration of 10 - 50 µg/ml. For paraffin sections antigen retrieval is recommended.
    IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
    WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 28 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
    • Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
    • Involvement in diseaseCongenital central hypoventilation syndrome
    • Sequence similaritiesBelongs to the NGF-beta family.
    • Post-translational
      modifications
      The propeptide is N-glycosylated and glycosulfated.
      Converted into mature BDNF by plasmin (PLG).
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Abrineurin antibody
      • BDNF antibody
      • BDNF_HUMAN antibody
      • Brain derived neurotrophic factor antibody
      • Brain-derived neurotrophic factor antibody
      see all

    References for Anti-proBDNF antibody (ab72440)

    This product has been referenced in:
    • Scaini G  et al. Chronic administration of branched-chain amino acids impairs spatial memory and increases brain-derived neurotrophic factor in a rat model. J Inherit Metab Dis : (2012). WB . Read more (PubMed: 23109061) »
    • Cortese GP  et al. Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLC{gamma}1, and ERK in Hippocampal Synaptoneurosomes. J Neurosci 31:4274-9 (2011). WB ; Rat . Read more (PubMed: 21411668) »

    See all 2 Publications for this product

    Product Wall

    DISCOUNT CODE: ***

    Expiration date: August 19th, 2012

    I am very pleased to hear you would like to accept our offer and test ab72440 in IHC-FoFr. This code will give you: 1 free primary antibody before the expiration date. To redeem...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"