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Overview

  • Product nameAnti-proBDNF antibodySee all proBDNF primary antibodies ...
  • Description
    Chicken polyclonal to proBDNF
  • Tested applicationsWB, IP, IHC-Fr, ICC more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Fusion protein from mouse proBDNF containing only the prodomain region.

Properties

Applications

Our Abpromise guarantee covers the use of ab78367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IP
IHC-Fr
ICC
  • Application notesICC: 1/100 - 1/200.
    IHC-Fr: 1/100 - 1/250.
    IP: 1/100.
    WB: 1/500 - 1/1000. Predicted molecular weight: 28 kDa. Reacts with bands of 30 kD and 28 kD.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceBrain derived neurotrophic factor (BDNF)is a member of the nerve growth factor family. BDNF is necessary for survival of striatal neurons in the brain and also acts as a neuroprotectant of the major neuronal types (eg. hippocampal, cortical and basal forebrain cholinergic neurons). Expression of the BDNF gene is reduced in both Alzheimer's and Huntington disease patients. Furthermore BDNF may play a role in the regulation of stress response and in the biology of mood disorders. BDNF protein is synthesized as a precursor, proBDNF, which is cleaved to the mature 14-kDa form. It is known that BDNF exists as a mixture of proBDNF and mature BDNF (PMID: 1265414). Although the biological activity of proBDNF is unclear, there is evidence suggesting that reductions in proBDNF levels affects neuronal degeneration in selective brain regions (eg. in Alzheimer's disease).
    • Cellular localizationSecreted
    • Database links
      • Alternative names
          Abrineurin antibodyBrain derived neurotrophic factor antibodyBrain derived neurotrophic factor transcript IIa antibody
          Brain derived neurotrophic factor transcript IIb antibodyBrain derived neurotrophic factor transcript IIc antibodyBrain derived neurotrophic factor transcript III antibodyBrain derived neurotrophic factor transcript IV antibody
        see all

      References for Anti-proBDNF antibody (ab78367)

      ab78367 has not yet been referenced specifically in any publications.

      Publishing research using ab78367 ? Please let us know so that we can cite the reference in this datasheet

      Product Wall

      Submit an Abreview for ab78367 Submit a Question for ab78367

      Displaying 1 - 3 of 3 results for Abreviews and Q&A

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      Votes: Highest First

      People in one of our research project are interested in BDNF (brain derived neurotrophic factor). We’d like to know if there are antibodies which recognize only either the premature form or mature form of BDNF molecule?

      Thank you very much...

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      Thank you for contacting us.
      We have quite a few antibodies for BDNF. The antibodies ab108319, ab108383 ab109049 or ab72439 are against mature BDNF however ab78367 would detect the pro form.
      I hope this information is helpful to you. Please do n...

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      Will this antibody react with mature isoforms of BDNF? How was the specificity tested?

      Thank you for contacting Abcam regarding ab78367. This antibody was originally described in Beattie MS et al., 2002, Neuron 36, 375-86. The immunogen used to create this antibody was from within the prodomain of the protein, thus, this antibody will not r...

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      What is the estimated concentration of this proBDNF antibody?

      Thank you for contacting us. The proBDNF antibody ab78367 is semi-purified IgY from chicken yolk and serum. We do not measure the concentration for each lot of this antibody, but a previous lot was tested at 16 mg/ml. Typically concentrations in the r...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"