Overview

  • Product name
  • Description
    Rabbit polyclonal to proANP
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-101 of Human proANP. (Uniprot: P01160)

  • Positive control
    • NT2D1 whole cell lysate, PC-3 whole cell lysate, Mouse heart whole cell lysate, Human Hepatoma tissue and Human muscle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab126149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 16 kDa.
IHC-P 1/100 - 1/500. Perform antigen retrieval using heat mediated 10mM Citrate buffer(pH6.0) or Tris-EDTA buffer (pH8.0)

Target

  • Function
    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • Involvement in disease
    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • Sequence similarities
    Belongs to the natriuretic peptide family.
  • Post-translational
    modifications
    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • ATRST2 antibody
    • Cardiodilatin antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • Natriuretic peptides A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    • Pronatriodilatin antibody
    see all

Images

  • All lanes : Anti-proANP antibody (ab126149) at 1/1000 dilution

    Lane 1 : NT2D1 whole cell lysate
    Lane 2 : PC-3 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 16 kDa
  • Anti-proANP antibody (ab126149) at 1/5000 dilution + Mouse heart whole cell lysate at 50 µg

    Predicted band size : 16 kDa
  • ab126149, at 1/500 dilution, staining proANP in Formalin-fixed, Paraffin-embedded Human hepatoma tissue by Immunohistochemistry.
  • ab126149, at 1/500 dilution, staining proANP in Formalin-fixed, Paraffin-embedded Human muscle tissue by Immunohistochemistry.

References

ab126149 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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