Anti-Probable hydrolase PNKD antibody (ab112936)

Overview

  • Product nameAnti-Probable hydrolase PNKD antibody
    See all Probable hydrolase PNKD primary antibodies
  • Description
    Rabbit polyclonal to Probable hydrolase PNKD
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 41-70 of Human Probable hydrolase PNKD (NP_001070867.1, NP_072094.1, NP_056303.3).

  • Positive control
    • Mouse liver tissue lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab112936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

Target

  • FunctionProbable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
  • Tissue specificityIsoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.
  • Involvement in diseaseDefects in PNKD are the cause of dystonia type 8 (DYT8) [MIM:118800]. DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face.
  • Sequence similaritiesBelongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • Post-translational
    modifications
    Isoform 2 is phosphorylated at Ser-121 upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Nucleus; Mitochondrion and Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2210013N15Rik antibody
    • 2810403H05Rik antibody
    • AI854243 antibody
    • BRAIN PROTEIN 17 antibody
    • BRP17 antibody
    • DYT8 antibody
    • FKSG19 antibody
    • FPD1 antibody
    • KIAA1184 antibody
    • KIPP1184 antibody
    • MNCb-5687 antibody
    • MR-1 antibody
    • MR1 antibody
    • Myofibrillogenesis regulator 1 antibody
    • Paroxysmal nonkinesiogenic dyskinesia protein antibody
    • PDC antibody
    • PKND1 antibody
    • Pnkd antibody
    • PNKD_HUMAN antibody
    • Probable hydrolase PNKD antibody
    • TAHCCP2 antibody
    • Trans-activated by hepatitis C virus core protein 2 antibody
    see all

Anti-Probable hydrolase PNKD antibody images

  • Anti-Probable hydrolase PNKD antibody (ab112936) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 43 kDa

References for Anti-Probable hydrolase PNKD antibody (ab112936)

ab112936 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step 8% goat serum/0.3%BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 0.3% · Temperature: 25°C
Antigen retrieval step None
Sample Mouse Tissue sections (brain)
Specification brain
Permeabilization Yes - 0.33% Triton X-100
Fixative Paraformaldehyde
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Submitted Aug 28 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"