Overview

  • Product name
  • Description
    Rabbit polyclonal to proBNP
  • Specificity
    ab32842 recognises Pro-Brain Natriuretic Peptide.
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human proBNP aa 104-123.
    Sequence:

    PKMVQGS GCFGRKMDRI SSS

Properties

Applications

Our Abpromise guarantee covers the use of ab32842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 16-18 kDa.
IP 1/200. (1µl/250µg protein extract)

Target

  • Function
    Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • Tissue specificity
    Brain and also in atria, but at much lower levels than ANP.
  • Sequence similarities
    Belongs to the natriuretic peptide family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANFB_HUMAN antibody
    • BNP antibody
    • BNP(1-32) antibody
    • BNP(5-29) antibody
    • BNP-32 antibody
    • Brain type natriuretic peptide antibody
    • Gamma brain natriuretic peptide antibody
    • Gamma-brain natriuretic peptide antibody
    • Natriuretic peptide precursor B antibody
    • nppb antibody
    • NT proBNP antibody
    see all

References

This product has been referenced in:
  • Du CK  et al. Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy. Pharmacol Res Perspect 2:e00064 (2014). Read more (PubMed: 25505608) »
  • Li L  et al. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. J Mol Cell Cardiol : (2012). WB ; Mouse . Read more (PubMed: 22921782) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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