Biological descriptionNa+ channel blocker (IC50 = 60-200 μM). Local anaesthetic properties in vivo. Crosses the blood-brain barrier. Inhibits DNA methylation.
Also available in simple stock solutions (ab146726) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name4-Aminobenzoic acid 2-diethylaminoethyl ester hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Deffois A et al. Inhibition of synaptosomal veratridine-induced sodium influx by antidepressants and neuroleptics used in chronic pain. Neurosci Lett220:117-20 (1996).
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Usubiaga JE et al. Relationship between the passage of local anaesthetics across the blood-brain barrier and their effects on the central nervous system. Br J Anaesth39:943-7 (1967).
Read more (PubMed: 6082561) »