Anti-Procalcitonin antibody [44d9] (HRP) (ab14817)

Overview

  • Product nameAnti-Procalcitonin antibody [44d9] (HRP)
    See all Procalcitonin primary antibodies
  • Description
    Mouse monoclonal [44d9] to Procalcitonin (HRP)
  • ConjugationHRP
  • SpecificitySpecific for N-terminal fragment.
  • Tested applicationsSuitable for: ELISA, WB, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Native protein N-terminal fragment (purified) (Human) (see figure).

Properties

Applications

Our Abpromise guarantee covers the use of ab14817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 13 kDa.
Sandwich ELISA Use at an assay dependent dilution.

Target

  • RelevanceProcalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • CALC1 antibody
    • CALCA antibody
    • calcitonin related polypeptide alpha antibody
    • CGRP antibody
    • CGRP1 antibody
    • CT antibody
    • katacalcin antibody
    • KC antibody
    see all

References for Anti-Procalcitonin antibody [44d9] (HRP) (ab14817)

ab14817 has not yet been referenced specifically in any publications.

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