Overview

  • Product name
    Anti-proCathepsin D antibody
    See all proCathepsin D primary antibodies
  • Description
    Rabbit polyclonal to proCathepsin D
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse proCathepsin D. surrounding amino acid 140.
    Database link: P18242

  • Positive control
    • Human liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab190102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 45 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
  • Involvement in disease
    Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
  • Sequence similarities
    Belongs to the peptidase A1 family.
  • Cellular localization
    Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • CATD_HUMAN antibody
    • cathepsin D (lysosomal aspartyl protease) antibody
    • Cathepsin D antibody
    • Cathepsin D heavy chain antibody
    • Ceroid-lipofuscinosis, neuronal 10 antibody
    • CLN10 antibody
    • CPSD antibody
    • ctsd antibody
    • EC 3.4.23 antibody
    • EC 3.4.23.5 antibody
    • Lysosomal aspartyl peptidase antibody
    • Lysosomal aspartyl protease antibody
    • MGC2311 antibody
    • OTTHUMP00000042282 antibody
    • OTTHUMP00000196039 antibody
    • OTTHUMP00000198692 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human liver tissue labeling proCathespsin D with ab190102 at 5 µg/ml.

References

ab190102 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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