Anti-proCathepsin D antibody [AF4G5] (ab119710)

Overview

  • Product nameAnti-proCathepsin D antibody [AF4G5]
    See all proCathepsin D primary antibodies
  • Description
    Mouse monoclonal [AF4G5] to proCathepsin D
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant Human proCathepsin D purified from E.coli with His tag.

  • Positive control
    • MCF7, HepG2 and SK-BR3 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab119710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 45 kDa.

Target

  • FunctionAcid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
  • Involvement in diseaseDefects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
  • Sequence similaritiesBelongs to the peptidase A1 family.
  • Cellular localizationLysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • CATD_HUMAN antibody
    • cathepsin D (lysosomal aspartyl protease) antibody
    • Cathepsin D antibody
    • Cathepsin D heavy chain antibody
    • Ceroid-lipofuscinosis, neuronal 10 antibody
    • CLN10 antibody
    • CPSD antibody
    • ctsd antibody
    • EC 3.4.23 antibody
    • EC 3.4.23.5 antibody
    • Lysosomal aspartyl peptidase antibody
    • Lysosomal aspartyl protease antibody
    • MGC2311 antibody
    • OTTHUMP00000042282 antibody
    • OTTHUMP00000196039 antibody
    • OTTHUMP00000198692 antibody
    see all

Anti-proCathepsin D antibody [AF4G5] images

  • All lanes : Anti-proCathepsin D antibody [AF4G5] (ab119710) at 1/500 dilution

    Lane 1 : MCF7 cell lysate
    Lane 2 : HepG2 cell lysate
    Lane 3 : SK-BR3 cell lysate


    Predicted band size : 45 kDa

References for Anti-proCathepsin D antibody [AF4G5] (ab119710)

ab119710 has not yet been referenced specifically in any publications.

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