Anti-Procathepsin K antibody [4b9] (ab39246)

Overview

  • Product nameAnti-Procathepsin K antibody [4b9]
  • Description
    Mouse monoclonal [4b9] to Procathepsin K
  • SpecificityThis antibody is specific for Procathepsin K.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    N terminal His-tagged recombinant fusion protein (Human), produced in E. coli (36.7 kDa). It comprised 314 amino acid residues of the Human Procathepsin K and 12 additional amino acid residues (MRGSHHHHHHGS) - His Tag.

Properties

Applications

Our Abpromise guarantee covers the use of ab39246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 27 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionClosely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
  • Tissue specificityPredominantly expressed in osteclasts (bones).
  • Involvement in diseaseDefects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
  • Sequence similaritiesBelongs to the peptidase C1 family.
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cathepsin K antibody
    • Cathepsin O antibody
    • Cathepsin O1 antibody
    • Cathepsin O2 antibody
    • Cathepsin X antibody
    • CATK_HUMAN antibody
    • Ctsk antibody
    • CTSO antibody
    • CTSO2 antibody
    • PKND antibody
    • PYCD antibody
    see all

References for Anti-Procathepsin K antibody [4b9] (ab39246)

ab39246 has not yet been referenced specifically in any publications.

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