• Product nameAnti-PRODH antibody
    See all PRODH primary antibodies
  • Description
    Goat polyclonal to PRODH
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 84-98 of Human PRODH

  • Positive control
    • Human Brain lysates



Our Abpromise guarantee covers the use of ab48001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 60 kDa.
IHC-P Use a concentration of 3 - 6 µg/ml.


  • FunctionConverts proline to delta-1-pyrroline-5-carboxylate.
  • Tissue specificityExpressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • PathwayAmino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • Involvement in diseaseDefects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Sequence similaritiesBelongs to the proline oxidase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • HSPOX2 antibody
    • mitochondrial antibody
    • P53 induced gene 6 protein antibody
    • p53-induced gene 6 protein antibody
    • PIG6 antibody
    • POX antibody
    • PROD_HUMAN antibody
    • PRODH 1 antibody
    • PRODH 2 antibody
    • PRODH antibody
    • PRODH1 antibody
    • PRODH2 antibody
    • Proline dehydrogenase antibody
    • proline dehydrogenase (oxidase) 1 antibody
    • proline dehydrogenase (proline oxidase) antibody
    • Proline dehydrogenase 1 antibody
    • Proline dehydrogenase 1, mitochondrial antibody
    • Proline oxidase 1 antibody
    • Proline oxidase 2 antibody
    • Proline oxidase antibody
    • Proline oxidase, mitochondrial antibody
    • Proline oxidase, mitochondrial precursor antibody
    • SCZD4 antibody
    • TP53I6 antibody
    • tumor protein p53 inducible protein 6 antibody
    see all

Anti-PRODH antibody images

  • ab48001 at 3.8 µg/ml staining PRODH in Human cerebellum tissue by Immunohistochemistry (Formalin/PFA-Fixed paraffin-embedded sections).

References for Anti-PRODH antibody (ab48001)

This product has been referenced in:
  • Thompson T  et al. 1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53. Mol Cancer Ther 9:1158-68 (2010). WB ; Human . Read more (PubMed: 20406950) »

See 1 Publication for this product

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