Anti-ProDynorphin antibody (ab11137)
Key features and details
- Rabbit polyclonal to Dynorphin B
- Suitable for: IHC-Fr
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-ProDynorphin antibody -
Description
Rabbit polyclonal to Dynorphin B -
Host species
Rabbit -
Specificity
This antibody blocks specifically with leumorphin (rat only). Cells are found in the paraventricular and supraoptic nucleus and fibres in the lateral hypothalamus in rat brain of colchicine treated 4% FA perfused tissue. -
Tested applications
Suitable for: IHC-Frmore details -
Species reactivity
Reacts with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Rat ProDynorphin.
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General notes
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA, 5% Sucrose -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab11137 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr |
1/100 - 1/2000.
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Notes |
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IHC-Fr
1/100 - 1/2000. |
Target
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Function
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect. -
Involvement in disease
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. -
Sequence similarities
Belongs to the opioid neuropeptide precursor family. -
Post-translational
modificationsThe N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 18610 Mouse
- Entrez Gene: 29190 Rat
- SwissProt: O35417 Mouse
- SwissProt: P06300 Rat
- Unigene: 6239 Mouse
- Unigene: 44471 Rat
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Alternative names
- Beta-neoendorphin-dynorphin antibody
- Big Dyn antibody
- Dyn B antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab11137 has been referenced in 4 publications.
- Lee GJ et al. Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition. Neuroscience 495:58-73 (2022). PubMed: 35643248
- Whitfield TW et al. ? Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci 35:4296-305 (2015). PubMed: 25762676
- Romero-Picó A et al. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology 38:1296-307 (2013). PubMed: 23348063
- Schlosburg JE et al. Long-term antagonism of ? opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci 33:19384-92 (2013). Rat . PubMed: 24305833