Overview

  • Product nameAnti-Prokineticin 1 antibody
    See all Prokineticin 1 primary antibodies
  • Description
    Rabbit polyclonal to Prokineticin 1
  • SpecificityThe polyclonal antibody reacts specificly with human prokinectin 1.
  • Tested applicationsSuitable for: WB, Flow Cyt, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from N terminal region of Human prokinectin 1

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab42802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Predicted molecular weight: 12 kDa.Can be blocked with Prokineticin 1 peptide (ab206194).
Flow Cyt 1/100. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IHC-P 1/50.
IHC-Fr 1/50.

Target

  • FunctionPotently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
  • Tissue specificityLocalizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
  • Sequence similaritiesBelongs to the AVIT (prokineticin) family.
  • Developmental stageIn adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Black mamba toxin related protein antibody
    • EG VEGF antibody
    • EG-VEGF antibody
    • EGVEGF antibody
    • Endocrine-gland-derived vascular endothelial growth factor antibody
    • Mambakine antibody
    • PK1 antibody
    • PRK1 antibody
    • PROK1 antibody
    • PROK1_HUMAN antibody
    • Prokineticin-1 antibody
    see all

Anti-Prokineticin 1 antibody images

  • ab42802 at 0.33 µg/ml staining Prokinectin 1 in tissue of chorionic villi at 9 weeks of gestation. Staining can be observed in Cytotrophoblast (Cyt), Hobfauer cells (Ho), Extravillous trophoblast (Evt) and Syncytiotrophoblast (St). Negative control with preimmune serum shows no staining. Counterstaining performed with haematoxylin.

References for Anti-Prokineticin 1 antibody (ab42802)

ab42802 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"