Anti-Prokineticin 2/PK2 antibody (ab76747)
Key features and details
- Rabbit polyclonal to Prokineticin 2/PK2
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-Prokineticin 2/PK2 antibody
See all Prokineticin 2/PK2 primary antibodies -
Description
Rabbit polyclonal to Prokineticin 2/PK2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab76747 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/100 - 1/1000.
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Notes |
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IHC-P
1/100 - 1/1000. |
Target
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Function
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. -
Tissue specificity
Expressed in the testis and, at low levels, in the small intestine. -
Involvement in disease
Defects in PROK2 are the cause of Kallmann syndrome type 4 (KAL4) [MIM:610628]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. KAL4 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip/palate, selective tooth agenesis, and bimanual synkinesis. -
Sequence similarities
Belongs to the AVIT (prokineticin) family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 60675 Human
- Entrez Gene: 50501 Mouse
- Entrez Gene: 192206 Rat
- Omim: 607002 Human
- SwissProt: Q9HC23 Human
- SwissProt: Q9QXU7 Mouse
- SwissProt: Q8R413 Rat
- Unigene: 528665 Human
see all -
Alternative names
- BV8 antibody
- Bv8 homolog antibody
- MIT1 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (10)
ab76747 has been referenced in 10 publications.
- Schirinzi T et al. Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction. Brain Behav Immun 108:302-308 (2023). PubMed: 36549578
- Zhai J et al. Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization. Reprod Biol Endocrinol 20:76 (2022). PubMed: 35501804
- Morris EL et al. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. EMBO J 40:e108614 (2021). PubMed: 34487375
- Noda K et al. Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis. Sci Rep 11:18399 (2021). PubMed: 34526577
- Liu P et al. Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. Biosci Rep 40:N/A (2020). PubMed: 32285913
- Huang C et al. Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway. Oxid Med Cell Longev 2020:7075836 (2020). PubMed: 32922653
- Mundim MV et al. A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury. Mol Cell Neurosci 94:1-10 (2019). PubMed: 30391355
- Lattanzi R et al. Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology. Cells 8:N/A (2019). PubMed: 31766244
- Liu XQ et al. Relationship between PK2 and number of Kupffer cells during the progression of liver fibrosis in patients with HBV Turk J Med Sci 48:52-61 (2018). PubMed: 29479955
- Li Y et al. Effects of prokineticin 2 on testicular inflammation in rats. Am J Reprod Immunol 79:e12843 (2018). PubMed: 29516577