Anti-Prokineticin 2 antibody (ab76747)

Overview

  • Product nameAnti-Prokineticin 2 antibody
    See all Prokineticin 2 primary antibodies
  • Description
    Rabbit polyclonal to Prokineticin 2
  • Tested applicationsSuitable for: WB, IHC-Fr, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide derived from the C terminal region of human Prokineticin 2

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab76747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Predicted molecular weight: 14 kDa.Can be blocked with Prokineticin 2 peptide (ab140536).
IHC-Fr 1/100 - 1/1000.
IHC-P 1/100 - 1/1000.

Target

  • FunctionMay function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
  • Tissue specificityExpressed in the testis and, at low levels, in the small intestine.
  • Involvement in diseaseDefects in PROK2 are the cause of Kallmann syndrome type 4 (KAL4) [MIM:610628]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. KAL4 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip/palate, selective tooth agenesis, and bimanual synkinesis.
  • Sequence similaritiesBelongs to the AVIT (prokineticin) family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BV8 antibody
    • Bv8 homolog antibody
    • MIT1 antibody
    • PK2 antibody
    • PROK2 antibody
    • PROK2_HUMAN antibody
    • Prokineticin-2 antibody
    • Protein Bv8 homolog antibody
    see all

Anti-Prokineticin 2 antibody images

  • A: ab76747 staining Prokinectin 2 in Mouse testis by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
    B: Negative control treated with preimmune serum.
    Both sections counterstained with haematoxylin.

References for Anti-Prokineticin 2 antibody (ab76747)

ab76747 has not yet been referenced specifically in any publications.

Product Wall

Yes, the antibody does cross-react with rat PK2, and also mouse.

Yes ab76747 cross reacts with mouse.

Thank you for your response.

As in Point 2 in the previous e-mail describes, the discount code will be for the original value of the product. You can use and test different fixative to chec which one would work better in your experimental sys...

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Thank you very much for your interest our AbTrial program.


To our knowledge, ab76747 has not been tested in murine system. However by participating in our AbTrial program you can now use our products in an untested application or specie...

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Thank you for your inquiry.


I am happy to confirm that we now have added the blocking peptide for this antibody to out catalog.

Please follow this link to the datasheet of the blocking peptide:

ab140536

http...

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Thank you very much for your interest in ab76747.
To our knowledge, ab76747 has not been tested in radioimmunoassay (RIA) and we predict that mouse and rat tissue. Therefore, I can offer a discount off a future purchase if you buy ab76747 now, tes...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"