Overview

  • Product nameAnti-Prolactin Receptor antibody
    See all Prolactin Receptor primary antibodies
  • Description
    Rabbit polyclonal to Prolactin Receptor
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Orangutan
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Prolactin Receptor.

    (Peptide available as ab98251.)

  • Positive control
    • This antibody gave a positive signal in A431 whole cell lysate and the following tissue lysates: Human kidney; Human breast; Human liver.

Properties

Applications

Our Abpromise guarantee covers the use of ab87992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 73 kDa (predicted molecular weight: 69 kDa).

Target

  • FunctionThis is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
  • Tissue specificityExpressed in breast, placenta, kidney, liver and pancreas.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 1 subfamily.
    Contains 2 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationSecreted and Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI987712 antibody
    • CLONE SPM213 antibody
    • CPRLP antibody
    • Delta 4-delta 7/11 truncated prolactin receptor antibody
    • Delta 4-SF1b truncated prolactin receptor antibody
    • HPRL antibody
    • hPRL receptor antibody
    • hPRLrI antibody
    • Lactogen receptor antibody
    • MFAB antibody
    • MGC105486 antibody
    • OPR antibody
    • OTTHUMP00000115998 antibody
    • Pr-1 antibody
    • Pr-3 antibody
    • PRL R antibody
    • PRL-R antibody
    • PRLR antibody
    • Prlr-rs1 antibody
    • PRLR_HUMAN antibody
    • Prolactin receptor a antibody
    • Prolactin receptor antibody
    • Prolactin receptor delta 7/11 antibody
    • RATPRLR antibody
    • Secreted prolactin binding protein antibody
    • Truncated testis-specific box 1-C prolactin receptor antibody
    • wu:fj65c07 antibody
    see all

Anti-Prolactin Receptor antibody images

  • All lanes : Anti-Prolactin Receptor antibody (ab87992) at 1 µg/ml

    Lane 1 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : Human kidney tissue lysate - total protein (ab30203)
    Lane 3 : Human breast tissue lysate - total protein (ab30090)
    Lane 4 : Human liver tissue lysate - total protein (ab29889)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 69 kDa
    Observed band size : 73 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 61 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

References for Anti-Prolactin Receptor antibody (ab87992)

This product has been referenced in:
  • Neradugomma NK  et al. Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. Carcinogenesis N/A:N/A (2013). Read more (PubMed: 24265293) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"