Overview

  • Product name
    Anti-Properdin antibody [10-18]
    See all Properdin primary antibodies
  • Description
    Mouse monoclonal [10-18] to Properdin
  • Tested applications
    Suitable for: ELISA, IHC-Fr, Functional Studiesmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Native purified Properdin from human serum.

  • Positive control
    • Histology positive control tissue: Kidney from post streptococcal glomerulonephritis patients.

Properties

Applications

Our Abpromise guarantee covers the use of ab58984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-Fr
Functional Studies
  • Application notes
    ELISA: Use at an assay dependent dilution.
    FuncS: Use at an assay dependent dilution.
    Note: This antibody inhibits the function of Properdin. Removal of sodium azide is recommended prior to use in functional assays
    IHC-Fr: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
    • Involvement in disease
      Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
    • Sequence similarities
      Contains 6 TSP type-1 domains.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • BFD antibody
      • CFP antibody
      • Complement factor P antibody
      • Complement factor properdin antibody
      • Factor P antibody
      • PFC antibody
      • PFD antibody
      • PROP_HUMAN antibody
      • Properdin antibody
      • Properdin P factor complement antibody
      see all

    References

    ab58984 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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