Overview

  • Product nameAnti-Properdin antibody [3B10]
    See all Properdin primary antibodies
  • Description
    Mouse monoclonal [3B10] to Properdin
  • Specificityab25850 recognises human properdin.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Properdin isolated from human plasma.

  • EpitopeEpitope specificity differs from that of ab17780 but slightly overlap as determined by inhibition ELISA.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number3B10
  • Myelomax63-Ag8.653
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab25850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/8000. (based on use as detection antibody for antigen coated at 0.3 µg/ml).
WB Use at an assay dependent dilution. Recognises both reduced and unreduced forms of the protein.
AP Use at an assay dependent dilution. Suitable for affinity purification of human properdin after coupling to an activated CNBr-sepharose column.

Target

  • FunctionA positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
  • Involvement in diseaseDefects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
  • Sequence similaritiesContains 6 TSP type-1 domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BFD antibody
    • CFP antibody
    • Complement factor P antibody
    • Complement factor properdin antibody
    • Factor P antibody
    • PFC antibody
    • PFD antibody
    • PROP_HUMAN antibody
    • Properdin antibody
    • Properdin P factor complement antibody
    see all

References for Anti-Properdin antibody [3B10] (ab25850)

ab25850 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab25850.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"