Overview

  • Product name
    Anti-Properdin antibody [3B10]
    See all Properdin primary antibodies
  • Description
    Mouse monoclonal [3B10] to Properdin
  • Specificity
    ab25850 recognises human properdin.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Properdin isolated from human plasma.

  • Epitope
    Epitope specificity differs from that of ab17780 but slightly overlap as determined by inhibition ELISA.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    3B10
  • Myeloma
    x63-Ag8.653
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab25850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/8000. (based on use as detection antibody for antigen coated at 0.3 µg/ml).
WB Use at an assay dependent dilution. Recognises both reduced and unreduced forms of the protein.
AP Use at an assay dependent dilution. Suitable for affinity purification of human properdin after coupling to an activated CNBr-sepharose column.

Target

  • Function
    A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
  • Involvement in disease
    Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
  • Sequence similarities
    Contains 6 TSP type-1 domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BFD antibody
    • CFP antibody
    • Complement factor P antibody
    • Complement factor properdin antibody
    • Factor P antibody
    • PFC antibody
    • PFD antibody
    • PROP_HUMAN antibody
    • Properdin antibody
    • Properdin P factor complement antibody
    see all

References for Anti-Properdin antibody [3B10] (ab25850)

ab25850 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab25850.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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