The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC2, catalog ab3533. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
KEX2 like endoprotease 2
KEX2-like endoprotease 2
Neuroendocrine convertase 2
Prohormone convertase 2
Proprotein convertase 2
Proprotein convertase subtilisin/kexin type 2
FunctionInvolved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Sequence similaritiesBelongs to the peptidase S8 family. Furin subfamily.
Cellular localizationCytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
References for Proprotein Convertase 2 peptide (ab5012)
This product has been referenced in:
Helwig M et al. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol18:413-25 (2006).
Read more (PubMed: 16684131) »