Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC2, catalog ab3533. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • KEX2 like endoprotease 2
    • KEX2-like endoprotease 2
    • NEC 2
    • NEC2
    • NEC2_HUMAN
    • Neuroendocrine convertase 2
    • PC2
    • PCSK2
    • Prohormone convertase 2
    • Proprotein convertase 2
    • Proprotein convertase subtilisin/kexin type 2
    • SPC2
    see all
  • Function
    Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
  • Sequence similarities
    Belongs to the peptidase S8 family. Furin subfamily.
  • Cellular localization
    Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
  • Information by UniProt

References

This product has been referenced in:
  • Helwig M  et al. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol 18:413-25 (2006). Read more (PubMed: 16684131) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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