Overview

  • Product name
    Anti-Prorenin antibody (Biotin)
    See all Prorenin primary antibodies
  • Description
    Sheep polyclonal to Prorenin (Biotin)
  • Host species
    Sheep
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Recombinant full length protein (His-tag) corresponding to Mouse Prorenin aa 1-402. The glycosylated form was used as an immunogen.
    Database link: P06281

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 6.60
    Constituents: 0.71% Sodium phosphate, 0.58% Sodium chloride, 0.03% EDTA
  • Concentration information loading...
  • Purity
    Affinity purified
  • Purification notes
    Affinity purified by immobilized prorenin and biotin labeled.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab170077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 44 kDa.
ELISA Use at an assay dependent concentration.

Target

  • Function
    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • Involvement in disease
    Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • Sequence similarities
    Belongs to the peptidase A1 family.
  • Cellular localization
    Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt
  • Database links
  • Alternative names
    • Angiotensin forming enzyme antibody
    • Angiotensinogenase antibody
    • FLJ10761 antibody
    • HNFJ2 antibody
    • REN antibody
    • Ren1 antibody
    • RENAA antibody
    • RENI_HUMAN antibody
    • Renin antibody
    • Renin precursor renal antibody
    • Renin-1 antibody
    • Renin-2 antibody
    see all

References

ab170077 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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