Endogenous metabolite derived from arachidonic acid
Biological descriptionEndogenous metabolite derived from arachidonic acid. Plays a vital role in the induction of apoptosis. Blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase. Additionally acts as a vasodilator with natriuretic properties.
Chemical name(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-triene-1-oic acid
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSupplied in methyl acetate (10 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Lee SY et al. Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells. Prostaglandins Other Lipid Mediat91:30-7 (2010).
Read more (PubMed: 20044024) »
Hitomi M et al. Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. J Biol Chem271:9376-83 (1996).
Read more (PubMed: 8621603) »