Anti-Prostaglandin D Synthase (Lipocalin) antibody (ab167498)

Overview

  • Product name
    Anti-Prostaglandin D Synthase (Lipocalin) antibody
    See all Prostaglandin D Synthase (Lipocalin) primary antibodies
  • Description
    Mouse polyclonal to Prostaglandin D Synthase (Lipocalin)
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-190 of Human Prostaglandin D Synthase (Lipocalin) (NP_000945.3).

  • Positive control
    • Prostaglandin D Synthase (Lipocalin) transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab167498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa.

Target

  • Function
    Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
  • Tissue specificity
    Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.
  • Sequence similarities
    Belongs to the calycin superfamily. Lipocalin family.
  • Developmental stage
    Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy. Levels decrease slowly after 25 weeks.
  • Domain
    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Post-translational
    modifications
    Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.
  • Cellular localization
    Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm > perinuclear region. Secreted. Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta trace protein antibody
    • Beta-trace protein antibody
    • Cerebrin 28 antibody
    • Cerebrin-28 antibody
    • glutathione independent PGD synthase antibody
    • Glutathione independent PGD synthetase antibody
    • Glutathione-independent PGD synthase antibody
    • L PGDS antibody
    • Lipocalin type prostaglandin D synthase antibody
    • Lipocalin-type prostaglandin-D synthase antibody
    • LPGDS antibody
    • PDS antibody
    • PGD2 antibody
    • PGD2 synthase antibody
    • PGDS antibody
    • PGDS2 antibody
    • prostaglandin D synthase antibody
    • prostaglandin D2 synthase (21 kDa, brain) antibody
    • prostaglandin D2 synthase (brain) antibody
    • prostaglandin D2 synthase 21kDa (brain) antibody
    • Prostaglandin D2 synthase antibody
    • prostaglandin H2 D isomerase antibody
    • Prostaglandin-D2 synthase antibody
    • Prostaglandin-H2 D-isomerase antibody
    • PTGDS antibody
    • PTGDS_HUMAN antibody
    • RP23-47P18.11-006 antibody
    see all

Images

  • All lanes : Anti-Prostaglandin D Synthase (Lipocalin) antibody (ab167498) at 1 µg/ml

    Lane 1 : Prostaglandin D Synthase (Lipocalin) transfected 293T cell lysate
    Lane 2 : Non-transfected transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-Mouse IgG HRP at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 21 kDa

References

ab167498 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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