Recombinant
RabMAb

Anti-Prostaglandin dehydrogenase 1 antibody [EPR12348(B)] (ab178682)

Overview

  • Product name
    Anti-Prostaglandin dehydrogenase 1 antibody [EPR12348(B)]
    See all Prostaglandin dehydrogenase 1 primary antibodies
  • Description
    Rabbit monoclonal [EPR12348(B)] to Prostaglandin dehydrogenase 1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Prostaglandin dehydrogenase 1 aa 1-100. The exact sequence is proprietary.
    Database link: P15428

  • Positive control
    • Human placenta, Caco-2 and SW480 lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab178682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 29 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function
      Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
    • Tissue specificity
      Detected in colon epithelium (at protein level).
    • Involvement in disease
      Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
      Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
      Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
    • Sequence similarities
      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 15 hydroxyprostaglandin dehydrogenase [NAD+] antibody
      • 15 PGDH antibody
      • 15-hydroxyprostaglandin dehydrogenase [NAD+] antibody
      • 15-PGDH antibody
      • 15PGDH antibody
      • Hpgd antibody
      • Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody
      • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody
      • OTTHUMP00000218960 antibody
      • OTTHUMP00000219016 antibody
      • OTTHUMP00000219018 antibody
      • PGDH antibody
      • PGDH_HUMAN antibody
      • PGDH1 antibody
      • PHOAR1 antibody
      • Prostaglandin dehydrogenase 1 antibody
      • SDR36C1 antibody
      • Short chain dehydrogenase/reductase family 36C member 1 antibody
      see all

    Images

    • All lanes : Anti-Prostaglandin dehydrogenase 1 antibody [EPR12348(B)] (ab178682) at 1/1000 dilution

      Lane 1 : Human placenta lysates
      Lane 2 : Caco-2 lysates
      Lane 3 : SW480 lysates

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 29 kDa

    References

    ab178682 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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