The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Prostaglandin E Receptor EP4 antibody (ab45863)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostaglandin E receptor 4
Prostaglandin E receptor 4 subtype EP4
Prostaglandin E2 receptor
Prostaglandin E2 receptor EP4 subtype
Prostanoid EP4 receptor
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Tissue specificityHigh in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.