Major prostanoid; important precursor in eicosanoid synthesis
Biological descriptionMajor prostanoid; important precursor in eicosanoid synthesis. Formed following catalysis of arachidonic acid (AA) by COX and is subsequently converted by cell-specific synthases to form biologically active PGs and thromboxane.
Chemical name(5Z,9α,11α,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid
Storage instructionsStore at -80°C.
Solubility overviewSupplied in acetone (100 µg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Lin L et al. Expression of prostaglandin H2-mediated mechanism of vascular contraction in hypertensive rats. Relation to lipoxygenase and prostacyclin synthase activities. Circ Res74:197-205 (1994).
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Gorman RR et al. Inhibition of basal and hormone-stimulated adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide prostaglandin H2. J Biol Chem250:6460-3 (1975).
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