Overview

  • Product name
    Prostaglandin H2
  • Description
    Major prostanoid; important precursor in eicosanoid synthesis
  • Alternative names
    • PGH2
  • Biological description
    Major prostanoid; important precursor in eicosanoid synthesis. Formed following catalysis of arachidonic acid (AA) by COX and is subsequently converted by cell-specific synthases to form biologically active PGs and thromboxane.
  • Purity
    > 95%

Properties

  • Chemical name
    (5Z,9α,11α,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid
  • Molecular weight
    352.47
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H32O5
  • CAS Number
    42935-17-1
  • Storage instructions
    Store at -80°C.
  • Solubility overview
    Supplied in acetone (100 µg/ml)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCCCC[C@@H](O)/C=C/[C@H]1[C@@H]2OO[C@@H](C2)[C@H]1C/C=CCCCC(O)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Malhotra S  et al. COX inhibitors for airway inflammation. Expert Opin Ther Targets 16:195-207 (2012). Read more (PubMed: 22324934) »
  • Lin L  et al. Expression of prostaglandin H2-mediated mechanism of vascular contraction in hypertensive rats. Relation to lipoxygenase and prostacyclin synthase activities. Circ Res 74:197-205 (1994). Read more (PubMed: 8293559) »
  • Gorman RR  et al. Inhibition of basal and hormone-stimulated adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide prostaglandin H2. J Biol Chem 250:6460-3 (1975). Read more (PubMed: 169245) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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