Overview

  • Product nameProstaglandin J2
  • Description
    Endogenous product of inflammation; PGD2 analog
  • Alternative names
    • PGJ2
  • Biological descriptionEndogenous highly reactive product of inflammation. PGD2 analog. Potent neurotoxin and activator of PPARα and PPARγ. Able to trigger pro-apoptotic responses in neuronal cells.
  • Purity> 95%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120913 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Prostaglandin J2 images

    • ab80579 staining tau in SKNSH cells treated with prostaglandin J2 (ab120913), by ICC/IF. Expression of tau expression is restringed to the perinuclear zone with increased concentration of prostaglandin J2, as described in literature.
      The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120913 (prostaglandin J2) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab80579 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei (blue) were counterstained with DAPI and membrane is was stained using WGA (red).

    References for Prostaglandin J2 (ab120913)

    This product has been referenced in:
    • Arnaud LT  et al. Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. J Neurochem 110:328-42 (2009). Read more (PubMed: 19457109) »
    • Kliewer SA  et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-9 (1995). Read more (PubMed: 8521498) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"