Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionP28065
    • SequenceRVILGN/DELPKFYDE
    • Amino acids207 to 220

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    These peptides may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse proteasome 20S LMP2, catalog ab4944. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • Beta1i
    • Large multifunctional peptidase 2
    • Large multifunctional protease 2
    • LMP 2
    • LMP2
    • Low molecular mass protein 2
    • Macropain chain 7
    • MGC70470
    • Multicatalytic endopeptidase complex chain 7
    • OTTHUMP00000062982
    • Proteasome (prosome macropain) subunit beta type 9
    • proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
    • Proteasome beta 9 subunit
    • Proteasome catalytic subunit 1i
    • Proteasome chain 7
    • Proteasome related gene 2
    • Proteasome subunit beta 6i
    • Proteasome subunit beta type 9
    • Proteasome subunit beta type-9
    • Proteasome subunit beta-1i
    • PSB9_HUMAN
    • PSMB 9
    • PSMB6i
    • PSMB9
    • Really interesting new gene 12 protein
    • RING 12
    • RING12
    • RING12 protein
    see all
  • FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
  • Sequence similaritiesBelongs to the peptidase T1B family.
  • Developmental stageHighly expressed in immature dendritic cells (at protein level).
  • Post-translational
    modifications
    Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Proteasome 20S LMP2 peptide (ab4944)

ab4944 has not yet been referenced specifically in any publications.

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