Anti-Proteasome 26S S2/PSMD2 antibody (ab125914)
Key features and details
- Rabbit polyclonal to Proteasome 26S S2/PSMD2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-Proteasome 26S S2/PSMD2 antibody
See all Proteasome 26S S2/PSMD2 primary antibodies -
Description
Rabbit polyclonal to Proteasome 26S S2/PSMD2 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis, Zebrafish -
Immunogen
Recombinant fragment corresponding to Human Proteasome 26S S2/PSMD2 aa 504-746.
Database link: Q13200 -
Positive control
- 293T, A431 and Raji cell lysates and Human A431 cells.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab125914 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 100 kDa.
|
|
ICC/IF |
1/100 - 1/500.
|
Notes |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 100 kDa. |
ICC/IF
1/100 - 1/500. |
Target
-
Function
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. -
Tissue specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta. -
Sequence similarities
Belongs to the proteasome subunit S2 family.
Contains 7 PC repeats. - Information by UniProt
-
Database links
- Entrez Gene: 5708 Human
- Entrez Gene: 21762 Mouse
- Entrez Gene: 287984 Rat
- Omim: 606223 Human
- SwissProt: Q13200 Human
- SwissProt: Q8VDM4 Mouse
- SwissProt: Q4FZT9 Rat
- Unigene: 518464 Human
see all -
Alternative names
- 26S proteasome non-ATPase regulatory subunit 2 antibody
- 26S proteasome regulatory subunit RPN1 antibody
- 26S proteasome regulatory subunit S2 antibody
see all
Images
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (1)
ab125914 has been referenced in 1 publication.
- Ou Q et al. TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4. Nat Commun 12:3481 (2021). PubMed: 34108482