The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesELISA: detection limit 1/16000.
WB: Use at a concentration of 0.03-0.3 µg/ml. Predicted molecular weight: 100 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionActs as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Tissue specificityFound in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Sequence similaritiesBelongs to the proteasome subunit S2 family. Contains 7 PC repeats.