Protein A is a surface protein of S.aureus which binds IgG molecules by their Fc region. In serum, the bacteria will bind IgG molecules in the wrong orientation on their surface which hinders opsonization and phagocytosis. Mutants of S. aureus lacking protein A are more efficiently phagocytosed in vitro, and mutants in infection models have diminished virulence.
Due to its affinity for the Fc region of many mammalian immunoglobulins, protein A is considered a universal reagent in biochemistry and immunology.
Secreted; cell wall.
gG-binding protein A antibody
Immunoglobulin G binding protein A antibody
Staphylococcal protein A antibody
Western blot - Anti-Protein A antibody (ab183882)
Lane 1 : Anti-Protein A antibody (ab183882) at 1/10000 dilution Lane 2 : GFP antibody at 1/10000 dilution
All lanes : Protein A, 0.1 ng
Predicted band size: 56 kDa
Easy blocker was used to block interaction of protein A with secondary antibody.