Anti-ATOH8 antibody (ab106377)
Key features and details
- Rabbit polyclonal to ATOH8
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-ATOH8 antibody -
Description
Rabbit polyclonal to ATOH8 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Synthetic peptide corresponding to Human ATOH8 (C terminal).
Database link: NP_116216 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106377 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa. |
Target
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Function
Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation. -
Tissue specificity
Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical vessels. -
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 71093 Mouse
- SwissProt: Q99NA2 Mouse
- Unigene: 87449 Mouse
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Form
Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation. Efficient DNA binding requires dimerization with another bHLH protein. Contains 1 basic helix-loop-helix (bHLH) domain. Cellular localisation: nucleus. -
Alternative names
- 4933425C05Rik antibody
- ATOH8 antibody
- ATOH8_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab106377 has been referenced in 5 publications.
- Mao Q et al. CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis. Am J Cancer Res 10:3194-3211 (2020). PubMed: 33163265
- Chen L et al. ATOH8 overexpression inhibits the tumor progression and monocyte chemotaxis in hepatocellular carcinoma. Int J Clin Exp Pathol 13:2534-2543 (2020). PubMed: 33165366
- Ye M et al. High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression. Oncol Rep 37:2955-2963 (2017). PubMed: 28393252
- Wang Z et al. Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma. Oncotarget 7:26765-79 (2016). WB . PubMed: 27049918
- Fang F et al. The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function. J Cell Sci 127:1428-40 (2014). WB ; Human . PubMed: 24463812