• Product nameAnti-Protein C antibody
    See all Protein C primary antibodies
  • Description
    Sheep polyclonal to Protein C
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human): Protein C

  • General notesOD280nm, E1% = 14)



Our Abpromise guarantee covers the use of ab28663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.


  • FunctionProtein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
  • Tissue specificityPlasma; synthesized in the liver.
  • Involvement in diseaseThrombophilia due to protein C deficiency, autosomal dominant
    Thrombophilia due to protein C deficiency, autosomal recessive
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
    N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
  • Cellular localizationSecreted. Golgi apparatus. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activation peptide antibody
    • Anticoagulant protein C antibody
    • APC antibody
    • Autoprothrombin IIA antibody
    • Blood coagulation factor XIV antibody
    • EC antibody
    • PC antibody
    • proC antibody
    • PROC_HUMAN antibody
    • PROC1 antibody
    • Protein C (inactivator of coagulation factors Va and VIIIa) antibody
    • THPH3 antibody
    • THPH4 antibody
    • Vitamin K dependent protein C antibody
    see all

Anti-Protein C antibody images

  • Predicted band size : 52 kDa

    Image from Ní Ainle F et al, J Biol Chem. 2011 Jan 14;286(2):1323-30. Epub 2010 Nov 2, Fig 1. DOI 10.1074/jbc.M110.159475

References for Anti-Protein C antibody (ab28663)

This product has been referenced in:
  • Ní Ainle F  et al. Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem 286:1323-30 (2011). WB ; Human . Read more (PubMed: 21044954) »

See 1 Publication for this product

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All of these antibodies are raised against full length Protein C. So we do not know what epitope(s) will be recognized by these antibodies.

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