Anti-Protein C antibody (ab61363)

Overview

  • Product nameAnti-Protein C antibody
    See all Protein C primary antibodies
  • Description
    Mouse monoclonal to Protein C
  • SpecificityRecognises protein C and activated protein C
  • Tested applicationsSuitable for: WB, ELISA, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native purified Human Protein C

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, Water
  • Concentration information loading...
  • PurityIon Exchange Chromatography
  • Purification notesSalt fractionation followed by gel filtration and ion exchange chromatography
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab61363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 52 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • FunctionProtein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
  • Tissue specificityPlasma; synthesized in the liver.
  • Involvement in diseaseThrombophilia due to protein C deficiency, autosomal dominant
    Thrombophilia due to protein C deficiency, autosomal recessive
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
    N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
  • Cellular localizationSecreted. Golgi apparatus. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activation peptide antibody
    • Anticoagulant protein C antibody
    • APC antibody
    • Autoprothrombin IIA antibody
    • Blood coagulation factor XIV antibody
    • EC 3.4.21.69 antibody
    • PC antibody
    • proC antibody
    • PROC_HUMAN antibody
    • PROC1 antibody
    • Protein C (inactivator of coagulation factors Va and VIIIa) antibody
    • THPH3 antibody
    • THPH4 antibody
    • Vitamin K dependent protein C antibody
    see all

References for Anti-Protein C antibody (ab61363)

ab61363 has not yet been referenced specifically in any publications.

Product Wall

I'm happy to help! Please let me know if you need anything further.

Thank you for your enquiry.

All of these antibodies are raised against full length Protein C. So we do not know what epitope(s) will be recognized by these antibodies.

I hope this is helpful. Please contact us again if you have any ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"