Anti-Protein phosphatase 1 gamma 2 antibody (ab33634)

Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab33634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesELISA: > 5000 assays/mg.
    WB: 1/100. Predicted molecular weight: 36 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProtein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
    • Sequence similaritiesBelongs to the PPP phosphatase family. PP-1 subfamily.
    • Post-translational
      modifications
      Phosphorylated by NEK2.
    • Cellular localizationCytoplasm. Nucleus. Nucleus > nucleolus. Nucleus > nucleoplasm. Nucleus speckle. Chromosome > centromere > kinetochore. Cleavage furrow. Midbody. Mitochondrion. Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase.
    • Information by UniProt
    • Database links
    • Alternative names
      • ppp1cc-a antibody
      • PP 1G antibody
      • PP-1G antibody
      • PP1 antibody
      • PP1C antibody
      • PP1G antibody
      • PP1G_HUMAN antibody
      • PPP1CC antibody
      • PPP1G antibody
      • Protein phosphatase 1 catalytic subunit gamma isoform antibody
      • Protein phosphatase 1, catalytic subunit, gamma isozyme antibody
      • Protein phosphatase 1C catalytic subunit antibody
      • Serine/threonine phosphatase 1 gamma antibody
      • Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody
      • Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody
      see all

    References for Anti-Protein phosphatase 1 gamma 2 antibody (ab33634)

    ab33634 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"