Anti-Protein phosphatase 1 inhibitor 3C antibody (ab123016)

Overview

  • Product name
    Anti-Protein phosphatase 1 inhibitor 3C antibody
    See all Protein phosphatase 1 inhibitor 3C primary antibodies
  • Description
    Rabbit polyclonal to Protein phosphatase 1 inhibitor 3C
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 34-83 (PPVKSFLGPY DEFQRRHFVN KLKPLKSCLN IKHKAKSQND WKCSHNQAKK) of Human Protein phosphatase 1 inhibitor 3C (NP_005389).

  • Positive control
    • 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab123016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
  • Sequence similarities
    Contains 1 CBM21 (carbohydrate binding type-21) domain.
  • Domain
    The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
  • Post-translational
    modifications
    Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • OTTHUMP00000020089 antibody
    • Phosphatase 1, regulatory inhibitor subunit 5 antibody
    • PP1 subunit R5 antibody
    • ppp1r3c antibody
    • PPP1R5 antibody
    • PPR3C_HUMAN antibody
    • Protein phosphatase 1 regulatory subunit 3C antibody
    • Protein phosphatase 1 regulatory subunit 5 antibody
    • protein phosphatase 1, regulatory (inhibitor) subunit 3C antibody
    • Protein targeting to glycogen antibody
    • PTG antibody
    • R5 antibody
    see all

Images

  • Anti-Protein phosphatase 1 inhibitor 3C antibody (ab123016) at 1 µg/ml + 293T cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP

    Predicted band size : 36 kDa

References

ab123016 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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