Anti-Protein S antibody (ab61364)

Overview

  • Product nameAnti-Protein S antibody
    See all Protein S primary antibodies
  • Description
    Mouse monoclonal to Protein S
  • Tested applicationsSuitable for: WB, ELISA, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native purified Human Protein S

Properties

Applications

Our Abpromise guarantee covers the use of ab61364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 75 kDa.

Calcium dependent.

ELISA Use at an assay dependent concentration.

Calcium dependent.

RIA Use at an assay dependent concentration.

Calcium dependent.

Target

  • FunctionAnticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • Tissue specificityPlasma.
  • Involvement in diseaseDefects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
  • Sequence similaritiesContains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • Post-translational
    modifications
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Preproprotein S antibody
    • Propiece of latent protein S antibody
    • PROS 1 antibody
    • PROS antibody
    • PROS_HUMAN antibody
    • proS1 antibody
    • Protein S alpha antibody
    • Protein Sa antibody
    • PS 21 antibody
    • PS 22 antibody
    • PS 23 antibody
    • PS 24 antibody
    • PS 25 antibody
    • PS 26 antibody
    • PS21 antibody
    • PS22 antibody
    • PS23 antibody
    • PS24 antibody
    • PS25 antibody
    • PS26 antibody
    • PSA antibody
    • THPH5 antibody
    • THPH6 antibody
    • Vitamin K dependent protein S antibody
    • Vitamin K-dependent plasma protein S antibody
    • Vitamin K-dependent protein S antibody
    see all

References for Anti-Protein S antibody (ab61364)

ab61364 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 30 µg
Gel Running Conditions Reduced Denaturing
Sample Human Cell lysate - whole cell (macrophage)
Specification macrophage
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

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Verified customer

Submitted Dec 16 2014

Application ELISA
Sample Human Cell (human macrophages)
Specification human macrophages
Type Sandwich (Capture)
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

Abcam user community

Verified customer

Submitted Jan 08 2014

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I can confirm, that for most of our products we indeed have a clone number. I contacted our source and regrettably for the Anti-Protein S antibody is no clone number provided. Furthermore I can confirm that this prod...

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I can confirm that regrettably there is no clone number assigned for the Anti-Protein S antibody (ab61364). I would be pleased to help you further in this matter if you could give me additional information about wh...

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