Anti-Protor-1 antibody - C-terminal (ab185995)

Overview

  • Product name
    Anti-Protor-1 antibody - C-terminal
    See all Protor-1 primary antibodies
  • Description
    Rabbit polyclonal to Protor-1 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide within Human Protor-1 aa 338-388 (C terminal). The exact sequence is proprietary.
    Sequence:

    SSL PRSSPENLVD QILESVDSDS EGIFIDFGRG RGSGMSDLEG SGGRQSVV


    Database link: P85299

  • Positive control
    • 293T, HeLa, and Jurkat whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab185995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/20000 - 1/100000. Predicted molecular weight: 43 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
    • Tissue specificity
      Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
    • Sequence similarities
      Belongs to the PROTOR family.
    • Information by UniProt
    • Database links
    • Alternative names
      • Arhgap8 antibody
      • AU043908 antibody
      • C030017C09Rik antibody
      • C78947 antibody
      • FLJ20185 antibody
      • FLJ20185k antibody
      • MGC109513 antibody
      • MGC32512 antibody
      • PP610 antibody
      • Proline rich 5 (renal) antibody
      • Proline-rich protein 5 antibody
      • Protein observed with Rictor-1 antibody
      • Protor-1 antibody
      • PROTOR1 antibody
      • PRR5 antibody
      • PRR5_HUMAN antibody
      • PTOR1 antibody
      • Rho GTPase activating protein 8 antibody
      • RP1-181C9.3 antibody
      see all

    Images

    • All lanes : Anti-Protor-1 antibody - C-terminal (ab185995) at 0.1 µg/ml

      Lane 1 : 293T whole cell lysate
      Lane 2 : HeLa whole cell lysate
      Lane 3 : Jurkat whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 43 kDa


      Exposure time: 3 minutes

    References

    ab185995 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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