Anti-PROX1 antibody [5G10] (ab92825)


  • Product nameAnti-PROX1 antibody [5G10]
    See all PROX1 primary antibodies
  • Description
    Mouse monoclonal [5G10] to PROX1
  • SpecificitySpecific to PROX1
  • Tested applicationsSuitable for: IHC-FoFrmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Chicken, Human
    Predicted to work with: a wide range of other species
  • Immunogen

    Recombinant Human PROX1 protein.

  • Positive control
    • Rat denate gyrus tissue



Our Abpromise guarantee covers the use of ab92825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr 1/1000.


  • FunctionTranscription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • Tissue specificityMost actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • Sequence similaritiesBelongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • DomainThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Cellular localizationNucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • Database links
  • FormProx1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
  • Alternative names
    • Homeobox prospero like protein antibody
    • Homeobox prospero like protein PROX1 antibody
    • Homeobox prospero-like protein PROX1 antibody
    • Prospero homeobox 1 antibody
    • Prospero homeobox protein 1 antibody
    • Prospero related homeobox 1 antibody
    • prospero-related homeobox gene 1 antibody
    • PROX 1 antibody
    • PROX-1 antibody
    • PROX1 antibody
    • PROX1_HUMAN antibody
    • zgc:111888 antibody
    see all

Anti-PROX1 antibody [5G10] images

  • ab92825, at a 1/1000 dilution in 0.1% BSA with 0.25% triton-X-100 in 0.1 M tris-saline, staining PROX1 in rat dentate gyrus tissue by immunohistochemistry (perfusion). The tissue was fixed via transcaridal perfusion with 2% paraformaldehyde and 3.75% acrolein in 0.1 M phosphate buffer (pH 7.4). Detection: DAB staining (6 minutes)

References for Anti-PROX1 antibody [5G10] (ab92825)

ab92825 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (Brain)
Permeabilization Yes - 0.3% Triton x 100: 30 min
Specification Brain
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 37°C
Fixative Paraformaldehyde

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Submitted Dec 09 2016

Application Immunocytochemistry/ Immunofluorescence
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 37°C
Sample Mouse Cell (mouse lens tissue)
Specification mouse lens tissue
Permeabilization Yes - 0.25%triton for 12mins
Fixative Formaldehyde

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Submitted Jul 01 2013