Overview

  • Product nameAnti-PROX1 antibody
    See all PROX1 primary antibodies
  • Description
    Rabbit polyclonal to PROX1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, from around amino acids 723-727 (EIFKS) of Human PROX1.

  • Positive control
    • A431 cell extract

Properties

Applications

Our Abpromise guarantee covers the use of ab104629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 83 kDa.

Target

  • FunctionTranscription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • Tissue specificityMost actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • Sequence similaritiesBelongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • DomainThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Cellular localizationNucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • Database links
  • FormProx1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
  • Alternative names
    • Homeobox prospero like protein antibody
    • Homeobox prospero like protein PROX1 antibody
    • Homeobox prospero-like protein PROX1 antibody
    • Prospero homeobox 1 antibody
    • Prospero homeobox protein 1 antibody
    • Prospero related homeobox 1 antibody
    • prospero-related homeobox gene 1 antibody
    • PROX 1 antibody
    • PROX-1 antibody
    • PROX1 antibody
    • PROX1_HUMAN antibody
    • zgc:111888 antibody
    see all

Anti-PROX1 antibody images

  • All lanes : Anti-PROX1 antibody (ab104629) at 1/500 dilution

    Lane 1 : A431 cell extract with PROX1 blocking peptide
    Lane 2 : A431 cell extract


    Predicted band size : 83 kDa

References for Anti-PROX1 antibody (ab104629)

ab104629 has not yet been referenced specifically in any publications.

Product Wall

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